Active tuberculosis or other severe infections such as sepsis, and opportunistic infections. (see section 4.4 of the Summary of Product Characteristics).
Moderate to severe heart failure (NYHA class III/IV). (see section 4.4 of the Summary of Product Characteristics).
Hypersensitivity to the active substance or to any of the excipients listed (see section 6.1 of the Summary of Product Characteristics).